Burghardt Lab Hunter College - CUNY

Publications

2026

Vulnerability and Resilience to Activity-Based Anorexia is Not Sex-Dependent
Vulnerability and Resilience to Activity-Based Anorexia is Not Sex-Dependent
Julie Zhao, Jeff A. Beeler, Nesha S. Burghardt
openRxiv  ·  10 Jun 2026  ·  doi:10.64898/2026.06.05.730470
Methamphetamine conditioned place preference in adolescent mice: Interaction between sex and strain
Methamphetamine conditioned place preference in adolescent mice: Interaction between sex and strain
Lewis Nunez Severino, Andre B. Toussaint, Rachael M. Langa, Grace McKenna, Isabella A. Bodziony, Nesha S. Burghardt
Journal of Psychopharmacology  ·  28 Feb 2026  ·  doi:10.1177/02698811261420102

2025

Serotonergic modulation of the BNST-CeA pathway reveals sex differences in fear learning
Serotonergic modulation of the BNST-CeA pathway reveals sex differences in fear learning
Rebecca Ravenelle, Jinah Lee, Carolina Fernandes-Henriques, Jia Liu, Allyson K. Friedman, Ekaterina Likhtik, Nesha S. Burghardt
Nature Neuroscience  ·  06 Aug 2025  ·  doi:10.1038/s41593-025-02025-x
Chronic social defeat stress gives rise to social avoidance through fear learning
Chronic social defeat stress gives rise to social avoidance through fear learning
Jinah Lee, Antonio Aubry, Sadiyah Hanif, Itamar S. Grunfeld, Ekaterina Likhtik, Nesha S. Burghardt
Behavioural Brain Research  ·  01 Jan 2025  ·  doi:10.1016/j.bbr.2024.115245
Social isolation during adolescence differentially affects spatial learning in adult male and female mice
Social isolation during adolescence differentially affects spatial learning in adult male and female mice
Sadiyah Hanif, Mia Sclar, Jinah Lee, Caleb Nichols, Ekaterina Likhtik, Nesha S. Burghardt
Learning & Memory  ·  01 Jan 2025  ·  doi:10.1101/lm.054059.124

2022

Elevated granulocyte colony stimulating factor scp CSF scp causes cerebellar deficits and anxiety in a model of scp CSF scp 1 receptor related leukodystrophy
Elevated granulocyte colony stimulating factor (CSF) causes cerebellar deficits and anxiety in a model of CSF‐1 receptor related leukodystrophy
Fabrizio Biundo, Violeta Chitu, Jaafar Tindi, Nesha S. Burghardt, Gabriel G. L. Shlager, …, Michael A. DeTure, Dennis W. Dickson, Zbignew K. Wszolek, Kamran Khodakhah, E. Richard Stanley
Glia  ·  26 Nov 2022  ·  doi:10.1002/glia.24310
The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa
The Rise and Fall of Dopamine: A Two-Stage Model of the Development and Entrenchment of Anorexia Nervosa
Jeff A. Beeler, Nesha S. Burghardt
Frontiers in Psychiatry  ·  11 Jan 2022  ·  doi:10.3389/fpsyt.2021.799548

2021

Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa
Vulnerable and Resilient Phenotypes in a Mouse Model of Anorexia Nervosa
Jeff A. Beeler, Devry Mourra, Roseanna M. Zanca, Abigail Kalmbach, Celia Gellman, …, Peter Serrano, Holly Moore, Stephen Rayport, Susana Mingote, Nesha S. Burghardt
Biological Psychiatry  ·  01 Dec 2021  ·  doi:10.1016/j.biopsych.2020.06.030
Persistent increases of PKMζ in memory activated neurons trace LTP maintenance during spatial long term memory storage
Persistent increases of PKMζ in memory‐activated neurons trace LTP maintenance during spatial long‐term memory storage
Changchi Hsieh, Panayiotis Tsokas, Alejandro Grau‐Perales, Edith Lesburguères, Joseph Bukai, …, Peter J. Bergold, James E. Cottrell, Juan Marcos Alarcon, André Antonio Fenton, Todd Charlton Sacktor
European Journal of Neuroscience  ·  28 Mar 2021  ·  doi:10.1111/ejn.15137
Commentary on Vulnerability and Resilience to Activity-Based Anorexia and the Role of Dopamine
Commentary on Vulnerability and Resilience to Activity-Based Anorexia and the Role of Dopamine
Jeff A Beeler, Nesha S Burghardt
Journal of experimental neurology  ·  01 Mar 2021  ·  pmc:PMC7990270
Activity-based Anorexia for Modeling Vulnerability and Resilience in Mice
Activity-based Anorexia for Modeling Vulnerability and Resilience in Mice
Jeff Beeler, Nesha Burghardt
BIO-PROTOCOL  ·  01 Jan 2021  ·  doi:10.21769/BioProtoc.4009

2019

Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice
Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice
Valentina Bonnefil, Karen Dietz, Mario Amatruda, Maureen Wentling, Antonio V Aubry, …, Gary Temple, Hye-Jin Park, Nesha S Burghardt, Patrizia Casaccia, Jia Liu
eLife  ·  13 Aug 2019  ·  doi:10.7554/eLife.40855
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus
Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus
Victor M. Luna, Christoph Anacker, Nesha S. Burghardt, Hameda Khandaker, Valentine Andreu, …, Alessia Mastrodonato, Christine A. Denny, Andre A. Fenton, Helen E. Scharfman, Rene Hen
Science  ·  10 May 2019  ·  doi:10.1126/science.aat8789

2018

A diet enriched with curcumin promotes resilience to chronic social defeat stress
A diet enriched with curcumin promotes resilience to chronic social defeat stress
Antonio V. Aubry, Hameda Khandaker, Rebecca Ravenelle, Itamar S. Grunfeld, Valentina Bonnefil, Kenny L. Chan, Flurin Cathomas, Jia Liu, Glenn E. Schafe, Nesha S. Burghardt
Neuropsychopharmacology  ·  12 Dec 2018  ·  doi:10.1038/s41386-018-0295-2

2017

Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner
Serotonin inputs to the dorsal BNST modulate anxiety in a 5-HT1A receptor-dependent manner
A L Garcia-Garcia, S Canetta, J M Stujenske, N S Burghardt, M S Ansorge, A Dranovsky, E D Leonardo
Molecular Psychiatry  ·  01 Aug 2017  ·  doi:10.1038/mp.2017.165

2016

Molecular Mechanisms of Stress-Induced Increases in Fear Memory Consolidation within the Amygdala
Molecular Mechanisms of Stress-Induced Increases in Fear Memory Consolidation within the Amygdala
Antonio V. Aubry, Peter A. Serrano, Nesha S. Burghardt
Frontiers in Behavioral Neuroscience  ·  21 Oct 2016  ·  doi:10.3389/fnbeh.2016.00191

2015

Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells
Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells
Eun Hye Park, Nesha S. Burghardt, Dino Dvorak, René Hen, André A. Fenton
The Journal of Neuroscience  ·  19 Aug 2015  ·  doi:10.1523/JNEUROSCI.0885-15.2015
Suppression of Adult Neurogenesis Increases the Acute Effects of Kainic Acid
Suppression of Adult Neurogenesis Increases the Acute Effects of Kainic Acid
Sloka S. Iyengar, John J. LaFrancois, Daniel Friedman, Liam J. Drew, Christine A. Denny, Nesha S. Burghardt, Melody V. Wu, Jenny Hsieh, René Hen, Helen E. Scharfman
Experimental Neurology  ·  01 Feb 2015  ·  doi:10.1016/j.expneurol.2014.11.009

2013

Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits
Acute and chronic effects of selective serotonin reuptake inhibitor treatment on fear conditioning: Implications for underlying fear circuits
N.S. Burghardt, E.P. Bauer
Neuroscience  ·  01 Sep 2013  ·  doi:10.1016/j.neuroscience.2013.05.050
Chronic Antidepressant Treatment Impairs the Acquisition of Fear Extinction
Chronic Antidepressant Treatment Impairs the Acquisition of Fear Extinction
Nesha S. Burghardt, Torfi Sigurdsson, Jack M. Gorman, Bruce S. McEwen, Joseph E. LeDoux
Biological Psychiatry  ·  01 Jun 2013  ·  doi:10.1016/j.biopsych.2012.10.012
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
Mazen A. Kheirbek, Liam J. Drew, Nesha S. Burghardt, Daniel O. Costantini, Lindsay Tannenholz, Susanne E. Ahmari, Hongkui Zeng, André A. Fenton, René Hen
Neuron  ·  01 Mar 2013  ·  doi:10.1016/j.neuron.2012.12.038
A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment
A role for the extended amygdala in the fear-enhancing effects of acute selective serotonin reuptake inhibitor treatment
S Ravinder, N S Burghardt, R Brodsky, E P Bauer, S Chattarji
Translational Psychiatry  ·  15 Jan 2013  ·  doi:10.1038/tp.2012.137

2012

Adult born hippocampal neurons promote cognitive flexibility in mice
Adult‐born hippocampal neurons promote cognitive flexibility in mice
Nesha S. Burghardt, Eun Hye Park, René Hen, André A. Fenton
Hippocampus  ·  19 Mar 2012  ·  doi:10.1002/hipo.22013

2011

4 to 6 week old adult born hippocampal neurons influence novelty evoked exploration and contextual fear conditioning
4‐ to 6‐week‐old adult‐born hippocampal neurons influence novelty‐evoked exploration and contextual fear conditioning
Christine A. Denny, Nesha S. Burghardt, Daniel M. Schachter, René Hen, Michael R. Drew
Hippocampus  ·  07 Jul 2011  ·  doi:10.1002/hipo.20964
The absence of the calcium buffering protein calbindin is associated with faster age related decline in hippocampal metabolism
The absence of the calcium‐buffering protein calbindin is associated with faster age‐related decline in hippocampal metabolism
Herman Moreno, Nesha S. Burghardt, Daniel Vela‐Duarte, James Masciotti, Fan Hua, André A. Fenton, Beat Schwaller, Scott A. Small
Hippocampus  ·  31 May 2011  ·  doi:10.1002/hipo.20957
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
Amar Sahay, Kimberly N. Scobie, Alexis S. Hill, Colin M. O’Carroll, Mazen A. Kheirbek, Nesha S. Burghardt, André A. Fenton, Alex Dranovsky, René Hen
Nature  ·  01 Apr 2011  ·  doi:10.1038/nature09817

2007

Acute Selective Serotonin Reuptake Inhibitors Increase Conditioned Fear Expression: Blockade With a 5-HT2C Receptor Antagonist
Acute Selective Serotonin Reuptake Inhibitors Increase Conditioned Fear Expression: Blockade With a 5-HT2C Receptor Antagonist
Nesha S. Burghardt, David E.A. Bush, Bruce S. McEwen, Joseph E. LeDoux
Biological Psychiatry  ·  01 Nov 2007  ·  doi:10.1016/j.biopsych.2006.11.023

2004

The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine
The selective serotonin reuptake inhibitor citalopram increases fear after acute treatment but reduces fear with chronic treatment: a comparison with tianeptine
Nesha S. Burghardt, Gregory M. Sullivan, Bruce S. McEwen, Jack M. Gorman, Joseph E. LeDoux
Biological Psychiatry  ·  01 Jun 2004  ·  doi:10.1016/j.biopsych.2004.02.029